Creepies 2: Las Vegas Attack (2005)

"King Spider vs. the Mecha-Destructor."

With Los Angeles in flaming ruins from a nuclear attack, solders mop up what is left of the deadly spider with a giant spider killing robot: Mecha-Destructor. Unfortunately, a terrorist escaped from the weapons base with a suit case full of the creatures. Shot down behind the Beluxor Hotel, the spiders make their way in the pyramid and up and down the strip devouring gamblers, show girls and destroying many landmarks.